025 Methylation Insights Improve Treatment Outcomes – Walsh

methylation, overmethylation, undermethylation, dr william walsh, depression, biomedical

Methylation Details For Treatment Failure
The CoreBrain Journal Walsh Molecular Series: 1 of 3

More than two-thirds of persons diagnosed with a behavior or mental disorder exhibit a methylation imbalance. A person’s methyl status is established during the first few months of in-utero development and this condition tends to persist throughout life.
~ William Walsh

Agenda: The Walsh Molecular Series 

  1. Methylation – CBJ/025 – Each is a 1-hour Special Interview | UpdateCBJ/115
  2. Copper & Kryptopyrrole – CBJ/034 Active Link | Cu & Kp UpdateCBJ/137
  3. Schizophrenia & Bipolar – CBJ/042 Active Link
  4. The End of Autism -CBJ/141 – Link

Methylation Overview: Two-Thirds, 66%, Is A Remarkable Number

Molecular measures change the rules of the diagnostic and treatment game. Why? Improved target recognition for contributory molecular mind variables offers increased precision and more predictable outcomes.  It’s a terrific honor for me, and for our serious team at CoreBrain Journal, to welcome Dr. Walsh for this first in a special series of three one-hour CBJ indispensable interviews.

Why one hour? – Because Bill’s message is important for many reasons:

  1. Fresh, Relevant Data in a rapidly rising sea of excellent biomedical insights improves mind measurement and treatment initiatives for many who suffer from treatment failure.
  2. Cost-Effective Measures now reveal patterns of previously under-appreciated brain functions that look on the surface as untreatable – e.g. personality disorders, autism, mood disorders, schizophrenia, cognitive deterioration, ADHD.
  3. Understandable insights that lead to specific biomedical resolution strategies. Read his book. His molecular view arrives in different language packaging, and yet is quite easily translated into informed, effective clinical care by many.

About Dr. Walsh               

William J. Walsh, Ph.D., FACN, president of the non-profit Walsh Research Institute, is an internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine.  Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with behavioral disorders, attention deficit (hyperactivity) disorder, autism, clinical depression, anxiety, bipolar disorders, schizophrenia, and Alzheimer’s disease that are used by doctors throughout the world.

His book, Nutrient Power: Heal Your Biochemistry and Heal Your Brain [updated May 2014], describes specific findings for his evidence-based nutrient therapy system.

Dr. Walsh’s noted accomplishments include:  (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation and copper/zinc imbalances [Coming: CBJ/034] in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia [Coming: CBJ/042], and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning.

His internationally acclaimed presentations, including for the American Psychiatric Association, affirm his significant contributions to both functional and traditional medical groups.

methylation, kryptopyrrole, copper, bipolar, schizophrenia, anxiety,

Parker & Walsh: our first meeting: ACAM 2013

Clinical Experience

After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a Ph.D. in chemical engineering from Iowa State University.  While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior.

His collaboration with renowned (late) Carl C. Pfeiffer, MD, Ph.D., a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Dr. Walsh went on to study more than 30,000 patients with mental disorders acquiring an unparalleled database of more than 3 million chemical assays during his clinical and research work.

…misunderstandings and neglect create more confusion in this world than trickery and malice. At any rate, the last two are certainly much less frequent.
~ Goethe – 1774
Don’t assume bad intentions over neglect or misunderstanding.
~ Hanlon’s Razor – 1990

N.B. Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross.  He has assisted medical examiners, coroners, Scotland Yard, and the FBI in these forensics studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others.

Listen Up: MTHFR Genetic Testing Controversy Clarified

In this CBJ/025 interview, Dr. Walsh very carefully breaks down clinical/treatment limitations associated with the impressive rise and considerable attention regarding qualitative findings of MTHFR SNPs. The bottom line: if the results include MTHFR mutations one should not rush to judgment, to the result of using l-methyfolate to address SNP polymorphisms. L-methylfolate treatment can prove unpredictable without knowing the underlying overall quantitative methylation findings through either Whole Blood Histamine or SAMe/SAH ratio measures. Why? – Because it’s methyl – folate, not just folate. I’ve personally seen many patients who have become seriously over-methylated by missing the underlying overmethylation process and adding methylfolate.

Specific Folate Notes

Folate lowers serotonin, therefore will likely add to depression and anxiety if the person suffers from undermethylation – in brief undermethylation is more common – Listen to his details for a complete explanation:

  • Undermethylators/high histamine/”histadelia” = folate creates/aggravates symptoms by dropping synaptic serotonin
  • Overmethylators or low folate/low histamine/”histapenia” = here folate helps reduce symptoms by reducing increased synaptic levels

Start With This Important Methylation Finding:

Methylation is a biochemical process of extraordinary importance in human functioning. It may be defined as the addition of a methyl group (CH3) to an atom or molecule. Methyl groups participate in dozens of chemical reactions in the body and brain that are essential to physical and mental health. In addition, methylation status is a major factor in a person’s personality and traits. For example, undermethylation is associated with perfectionism, strong will, high accomplishment, OCD tendencies, and seasonal allergies. Typical features of overmethylation include excellent socialization skills, many friendships, non-competitiveness, artistic or musical interests, chemical and food sensitivities, and a tendency for high anxiety. [1]

Get on Dr. Walsh’s Book Drawing below – it’s closed in two weeks.


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Silicon Valley Institute 2015 | Advanced Nutrient Therapies – Dr. Walsh


Dr. Walsh’s Book & References:

  1. Walsh, Dr. William J. (Updated 2014-05-06). Nutrient Power: Heal Your Biochemistry and Heal Your Brain (p. 184). Skyhorse Publishing – essential. This first link is for paperback & hardcover. Sales here contribute to Dr. Walsh’s Nonprofit Research Group.  This link is for Global Amazon for Kindle & A Free Audible Copy Through This Link.
  2. Walsh Training For Professionals: http://www.walshinstitute.org/ – Oct. 15-18, ’16 Oak Park, IL. I’ll see you there.
  3. Multiple Walsh References and Downloads
  4. Epigenetics
  5. Advanced Nutrient Therapies For Mental Disorders – Walsh PowerPoint PDF – Nov. 2015
  6. Methylation at Nutrient Power Blog – Diagrams
  7. Preferred Testing Site: Direct Health Access Labs

Our Best Recommendation For Brain Recovery

Qualia – Our Most Recommended Nootropic | Brain Rehab Supplement – PDF: Where & How


CorePsych Videos And Multiple How-To Postings – The Walsh Process



CorePsych Tests | Video Explanations



Complimentary 025 Walsh Drawing Closes July 14, 2016

For: Nutrient Power – Heal Your Biochemistry and Heal Your Brain

– Enter The Drawing Here –



For An Easy 4 Page PDF Summary of Walsh Findings

Click Here to Download


Our Next CoreBrain Journal Episode

026: Dr. Rick Malter  One of the leading practitioners with in-depth clinical experience using TMA, Tissue Mineral Analysis through hair samples, to understand imbalances in mineral cofactors that directly affect the formation of neurotransmitters, thyroid, and adrenal dysfunction – and also serve as markers for autonomic nervous system balances. Dr. Malter has worked directly with Dr. David Watts, a thought leader in TMA research and practice,  and Dr. Malter’s book drawing at CBJ/026 on the use of Tissue Mineral evidence is one of the classics for this useful mind investigation tool.


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  1. […] at CBJ/028. [It’s second in total download numbers to Dr. Bill Walsh on Methylation at CBJ/025. We welcome our increasingly informed audience – just check out these two apparently arcane […]

  2. […] Start With This Important Methylation Finding […]

  3. […] Walsh after his first on the controversial and yet clinically useful measurement and treatment for Methylation issues [CBJ/025], and his second on the mind corruptions of Copper and Kryptopyrroles [CBJ/034].  Over the past 30 […]

  4. […] Epigenetic change addresses the critical, indeed essential, consequences of environmental change on our mind and body. If we don’t look, we can’t see. Genetics are heritable and remain fixed, while epigenetic change occurs as a consequence of the dynamics of reality experiences over our lifetimes – Stress does create epigenetic change. [Consider the profound neurotransmitter consequences of epigenetic change reviewed by Dr. Walsh during our discussion here at CBJ-025 on Methylation.] […]

  5. […] Methylation – CBJ/025 Published Start At This Link […]

  6. […] Walsh after his first on the controversial and yet clinically useful measurement and treatment for methylation issues [CBJ/025]. Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with […]

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