Methylation Details For Treatment Failure
The CoreBrain Journal Walsh Molecular Series: 1 of 3
More than two-thirds of persons diagnosed with a behavior or mental disorder exhibit a methylation imbalance. A person’s methyl status is established during the first few months of in-utero development and this condition tends to persist throughout life.
~ William Walsh
Agenda: The Walsh Molecular Series
- Methylation – CBJ/025 – Each a 1-hour Special Interview
- Copper & Kryptopyrrole – CBJ/034 Active Link
- Schizophrenia & Bipolar – CBJ/042 Active Link
Methylation Overview: Two-Thirds, 66%, Is A Remarkable Number
Molecular measures change the rules of the diagnostic and treatment game. Why? Improved target recognition for contributory molecular mind variables offers increased precision and more predictable outcomes. It’s a terrific honor for me, and for our serious team at CoreBrain Journal, to welcome Dr. Walsh for this first in a special series of three one-hour CBJ indispensable interviews.
Why one hour? – Because Bill’s message is important for many reasons:
- Fresh, Relevant Data in a rapidly rising sea of excellent biomedical insights improves mind measurement and treatment initiatives for many who suffer from treatment failure.
- Cost Effective Measures now reveal patterns of previously under-appreciated brain functions that look on the surface as untreatable – e.g. personality disorders, autism, mood disorders, schizophrenia, cognitive deterioration, ADHD.
- Understandable insights that lead to specific biomedical resolution strategies. Read his book. His molecular view arrives in different language packaging, and yet is quite easily translated into informed, effective clinical care by many.
About Dr. Walsh
William J. Walsh, Ph.D., FACN, president of the non-profit Walsh Research Institute, is an internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine. Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with behavioral disorders, attention deficit (hyperactivity) disorder, autism, clinical depression, anxiety, bipolar disorders, schizophrenia, and Alzheimer’s disease that are used by doctors throughout the world.
His book, Nutrient Power: Heal Your Biochemistry and Heal Your Brain [updated May 2014], describes specific findings for his evidence-based nutrient therapy system.
Dr. Walsh’s noted accomplishments include: (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation and copper/zinc imbalances [Coming: CBJ/034] in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia [Coming: CBJ/042], and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning.
His internationally acclaimed presentations, including for the American Psychiatric Association, affirm his significant contributions to both functional and traditional medical groups.
After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a Ph.D. in chemical engineering from Iowa State University. While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior.
His collaboration with renowned (late) Carl C. Pfeiffer, MD, Ph.D., a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Dr. Walsh went on to study more than 30,000 patients with mental disorders acquiring an unparalleled database of more than 3 million chemical assays during his clinical and research work.
…misunderstandings and neglect create more confusion in this world than trickery and malice. At any rate, the last two are certainly much less frequent.
~ Goethe – 1774
Don’t assume bad intentions over neglect or misunderstanding.
~ Hanlon’s Razor – 1990
N.B.: Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross. He has assisted medical examiners, coroners, Scotland Yard, and the FBI in these forensics studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others.
Listen Up: MTHFR Genetic Testing Controversy Clarified
In this CBJ/025 interview, Dr. Walsh very carefully breaks down clinical/treatment limitations associated with the impressive rise and considerable attention regarding qualitative findings of MTHFR SNPs. The bottom line: if the results include MTHFR mutations one should not rush to judgment, to the result of using l-methyfolate to address SNP polymorphisms. L-methylfolate treatment can prove unpredictable without knowing the underlying overall quantitative methylation findings through either Whole Blood Histamine or SAMe/SAH ratio measures. Why? – Because it’s methyl – folate.
Specific Folate Notes
Folate lowers serotonin, therefore will likely add to depression and anxiety if the person suffers from undermethylation – in brief undermethylation is more common – Listen to his details for a complete explanation:
- Undermethylators/high histamine/”histadelia” = folate creates/aggravates symptoms by dropping synaptic serotonin
- Overmethylators or low folate/low histamine/”histapenia” = here folate helps reduce symptoms by reducing increased synaptic levels
Start With This Important Methylation Finding:
Methylation is a biochemical process of extraordinary importance in human functioning. It may be defined as the addition of a methyl group (CH3) to an atom or molecule. Methyl groups participate in dozens of chemical reactions in the body and brain that are essential to physical and mental health. In addition, methylation status is a major factor in a person’s personality and traits. For example, undermethylation is associated with perfectionism, strong will, high accomplishment, OCD tendencies, and seasonal allergies. Typical features of overmethylation include excellent socialization skills, many friendships, non-competitiveness, artistic or musical interests, chemical and food sensitivities, and a tendency for high anxiety. 
Get on Dr. Walsh’s Book Drawing below – it’s closed in two weeks.
Easily Forward This Audio Message Link To a Friend
Silicon Valley Institute 2015 | Advanced Nutrient Therapies – Dr. Walsh
Dr. Walsh’s Book & References:
- Walsh, Dr. William J. (Updated 2014-05-06). Nutrient Power: Heal Your Biochemistry and Heal Your Brain (p. 184). Skyhorse Publishing – essential. This first link is for paperback & hardcover. Sales here contribute to Dr. Walsh’s Nonprofit Research Group. This link is for Global Amazon for Kindle & A Free Audible Copy Through This Link.
- Walsh Training For Professionals: http://www.walshinstitute.org/ – Oct. 15-18, ’16 Oak Park, IL. I’ll see you there.
- Multiple Walsh References and Downloads
- Advanced Nutrient Therapies For Mental Disorders – Walsh PowerPoint PDF – Nov. 2015
- Methylation at Nutrient Power Blog – Diagrams
CorePsych Videos And Multiple How-To Postings – The Walsh Process
CorePsych Tests | Video Explanations
Complimentary 025 Walsh Drawing Closes July 14, 2016
For: Nutrient Power Heal Your Biochemistry and Heal Your Brain
– Enter The Drawing Here –
For An Easy 4 Page PDF Summary of Walsh Findings
Our Next CoreBrain Journal Episode
026: Dr. Rick Malter One of the leading practitioners with in-depth clinical experience using TMA, Tissue Mineral Analysis through hair samples, to understand imbalances in mineral cofactors that directly affect the formation of neurotransmitters, thyroid, and adrenal dysfunction – and also serve as markers for autonomic nervous system balances. Dr. Malter has worked directly with Dr. David Watts, a thought leader in TMA research and practice, and Dr. Malter’s book drawing at CBJ/026 on the use of Tissue Mineral evidence is one of the classics for this useful mind investigation tool.
Produced By Studio Center – 7 Locations Nationally
- Top quality informationFebruary 5, 2017 by MD Ireland from Ireland
As a functional medicine doc I found this iterview stimulating, inspiring and it is full of clinically useful information
- FascinatingFebruary 1, 2017 by jinki1 from United States
If you love science and psychology, then this is for you. The brain is such a mysterious machine, and listening to experts discuss how it works is fascinating. This seems like a pick-and-choose type podcast: I'll skip the shows focusing on estrogen and alzeimer's and go for creativity, anxiety, music, and others. But what I've listened to so far is great.
- My Brain Thanks You!January 13, 2017 by B. Keenan Johnston from United States
Thanks for shedding some much needed light on issues of the brain. I recently became interested in the subject when I was listening to NPR do a segment on neuroplasticity. I could never remember the name of the author, but it helped me find this great podcast!
- Flipping Junkie ReviewDecember 23, 2016 by Danny Johnson -Flipping Junkie from United States
Awesome podcast! I really loved the bipolar episode. Wonderful insight into these issues. Keep up the good work!
- “How I Found Myself” Dean RobertsDecember 2, 2016 by Don Hutcheson from United States
I just had the pleasure of listening to Dr. Charles Parker’s latest interview with Mr. Dean Roberts on the topic: “How I Found Myself.” The thesis of this remarkable podcast is that the difference between treatment success and failure for conditions such as depression, anxiety, ADHD, PTSD and others is often the result of omitting crucial brain, biomedical, and functional neuroscience information and insights. Well done and much-needed. Wish you continuing success!
- I may be a geek...November 19, 2016 by JHHealy from United States
But as an addictions recovery coach I find this brain science utterly amazing! Great show, love it!
- Keep up the Great work Dr ChuckNovember 18, 2016 by imupat3am from United States
Just finished listening to the lateste episode with Dr Kelly Morrow-Baez the epsiode was about her and working with women ages 45-60.... Great podcast will be listening to more
- GROUND SHAKINGNovember 13, 2016 by Restlesstaxpayer from United States
Your shows are always very informative but the last two with Tom O'Brien andDavid Siever are absolutely revolutionary every doctor in the country should listen to both of them twice a day I cannot overstate how important this information is I am sending links to everyone I care about Thank you
- 21st Century PioneerSeptember 16, 2016 by Louis Di Bianco from Canada
Dr. Charles Parker offers us cutting edge knowledge in our rapidly changing world. The episde on music healing si a breath of fresh air. We need more natural healing alternatives like this one. It's easy to understand how music heals when you know that everything in our world is energy. Thank you for this important show.
- Episode 46 - such important work!September 16, 2016 by Michelle at Inner North Star from United States
I have done quite a bit of work around Post Traumatic Stress, being a Veteran and First Responder myself. This work with music/sound therapy is very interesting and this episode is well worth the listen. This podcast has relevant information we can all benfit from!
- Good StuffJuly 1, 2016 by namtrok from United States
While this is stuff I don't think of each day, Dr Charles presents it in a great way and I feel smarter each episode. Thanks! Paul from NomadTogether.com
- Very informative and filled with valueJune 19, 2016 by Jimwj from United States
This is an excellent podcast which provides smart, science-based, information which focuses on the mind and body. Great podcast. Check it out.
- Very informative!June 13, 2016 by Thomas O'Grady, PhD from United States
I’ve listened to a few episodes and this was an interesting podcast.
- Loved the episode with peggyJune 11, 2016 by Courageous1 from United States
Great work Charles - Love the episode with Peggy about anxiety. Keep it up!
- Fresh Mind ScienceJune 10, 2016 by ADHD reWired from United States
This is a great podcast for anyone interested in learning more about the brain and are looking for solutions. Great for clinicans, coaches and consumers. Thank you for creating this podcast!
- Valuable InformationJune 10, 2016 by dannytay92 from United States
Dr. Parker is a friendly, easy-to-listen to host, and this content is so valuable. All of us know people who could benefit from the specific topics of each episode.
- Truly Meaningful ContentJune 10, 2016 by No More Obstacles from United States
If you have a loved one with bipolar disorder or live with it yourself, do NOT miss that episode! Dr. Parker brings serious science to specific issues in an accesible, applicable way. Really, really good.
- Stellar podcast!May 27, 2016 by Justin D Williams from United States
I'm all about the mind and body connection, it's time we American's realize the power of both. There are so many amazing things to do in this world and I love that Dr. Parker is reminding us!
- This helpsMay 27, 2016 by JuneH78 from United States
My brother-in-law has bipolar and it's interesting to listen to this and hopefully better understand him. Very helpful!
- The Complex made Simple - #PWpeeps - Doc and JockApril 29, 2016 by JoeShu2326 from United States
The brain is complex and the issues surrounding often convoluted. Not on this podcast! Dr. parker breaks it down simply and concisely!
- FantasticApril 22, 2016 by HappyCoffeeLady44 from United States
Finally someone who brings the mind and body together!
- ExcellentApril 16, 2016 by M_Glover_88 from United Kingdom
This is a fantastic show. Really great info about a subject I have a huge interest in. Looking forward to more!
- Very smart podcast about the epic mind.April 16, 2016 by dustspecks from United States
Very smart host with very smart guest. This is a great show that can be utilized to dive into the inner workings of the mind and get up to date information about the mind.
- Excited!April 15, 2016 by SeeinADHD.com from United States
As an ADHD Coach, I'm excited to have another quality podcast to recommend to my clients. The mind and body are indeed connected, I'm looking forward to more!
- Excellent!!April 15, 2016 by Italykittyjc from United States
Excellent podcast with awesome content. Very well done. Very informative. Looking forward to listening to more episodes. Great job.